URSAHD (Unveiling RNA Sample Annotation for Human Diseases) measures hundreds of disease-specific signatures in a single gene expression profile. Each disease-specific model (i.e. gene weights) were computed based on thousands of clinical samples from GEO.
Reference: Lee YS, Krishnan A, Theesfeld CL, Rust J, Chang C, Oughtred R, Kristensen VN, Dolinski K, Troyanskaya OG. Genome-wide characterization of the human disease landscape. manuscript in preperation.
URSA(HD) was created by the Laboratory for bioinformatics and Functional Genomics in the Lewis-Sigler Institue for Integrative Genomics at Princeton University.